Design of incremental sigma-delta modulators with extended range for high-resolution analog-to-digital conversion of bioluminescence detection arrays [electronic resource] / Ali Agah

Agah, Ali.
Bib ID
vtls001343668
稽核項
107 p.
電子版
附註項
數位化論文典藏聯盟
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$a Design of incremental sigma-delta modulators with extended range for high-resolution analog-to-digital conversion of bioluminescence detection arrays $h [electronic resource] / $c Ali Agah
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$a 107 p.
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$a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6166.
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$a Adviser:  James D. Plummer.
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$a Thesis (Ph.D.)--Stanford University, 2007.
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$a There has recently been great interest in the development of low-cost, high-throughput de novo DNA sequencing platforms to pave the path towards next-generation genetic testing. A key challenge in the design of such platforms is the utilization of aggressive parallelization and miniaturization to increase the throughput and reduce the hardware and reagent costs. Miniaturization, however, comes at the cost of reduced signal levels which has to be compensated by the enhanced sensitivity of the detection system. CMOS technology provides a great toolset for implementing low-cost low-power custom solutions for integrated high-sensitivity detection. The flexibility provided through CMOS can be utilized to both enhance detection performance and lower costs. High-resolution analog-to-digital (A/D) conversion and digital signal processing can further reduce the minimum detection limit (MDL) of the DNA assays.
520
$a The focus of this research is to design a calibration-free high-resolution analog-to-digital converter (ADC) for a Pyrosequencing sensor array. The ADC can be used not only to push the quantization noise level down, but to calibrate nonlinearities in the sensing elements. A target specification of 1Msample/s conversion bandwidth and 15-bit resolution is targeted. The ADC is required to have the capability to perform conversion on a multiplexed input signal to address the entire sensor array. A high static linearity (on the order of the ADC resolution) ensures conversion accuracy with low-frequency sensor output signals.
520
$a Incremental sigma-delta (SigmaDelta modulators are a class of oversampling ADCs that combine the advantages of conventional SigmaDelta modulators with a multiplexing capability. The resolution of incremental SigmaDeltamodulators can be improved significantly by means of a technique similar to extended counting. In this scheme, the A/D conversion is accomplished in a two-step process resulting in enhanced resolution and an improved integral nonlinearity (INL) at lower oversampling ratios than would otherwise be possible. Calibration-free operation is an advantage of the proposed architecture.
520
$a An experimental implementation of the proposed modulator has been integrated in a 0.18mum CMOS technology. Operating form a 1.8V supply, it achieves a dynamic range of 90.1 dB and a peak SNDR of 86.3dB at a conversion rate of 1MSample/s with 38mW power consumption. It occupies an active area of 3.5mm 2.
591
$a 數位化論文典藏聯盟 $b PQDT $c 成功大學(2010)
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$a Biology, Genetics.
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$a Engineering, Electronics and Electrical.
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$a Stanford University.
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$a Dissertation Abstracts International ; $v 68-09B.
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$u http://info.lib.tku.edu.tw/ebook/redirect.asp?bibid=1343668
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叢書名
Dissertation Abstracts International ; 68-09B.
摘要
There has recently been great interest in the development of low-cost, high-throughput de novo DNA sequencing platforms to pave the path towards next-generation genetic testing. A key challenge in the design of such platforms is the utilization of aggressive parallelization and miniaturization to increase the throughput and reduce the hardware and reagent costs. Miniaturization, however, comes at the cost of reduced signal levels which has to be compensated by the enhanced sensitivity of the detection system. CMOS technology provides a great toolset for implementing low-cost low-power custom solutions for integrated high-sensitivity detection. The flexibility provided through CMOS can be utilized to both enhance detection performance and lower costs. High-resolution analog-to-digital (A/D) conversion and digital signal processing can further reduce the minimum detection limit (MDL) of the DNA assays.
The focus of this research is to design a calibration-free high-resolution analog-to-digital converter (ADC) for a Pyrosequencing sensor array. The ADC can be used not only to push the quantization noise level down, but to calibrate nonlinearities in the sensing elements. A target specification of 1Msample/s conversion bandwidth and 15-bit resolution is targeted. The ADC is required to have the capability to perform conversion on a multiplexed input signal to address the entire sensor array. A high static linearity (on the order of the ADC resolution) ensures conversion accuracy with low-frequency sensor output signals.
Incremental sigma-delta (SigmaDelta modulators are a class of oversampling ADCs that combine the advantages of conventional SigmaDelta modulators with a multiplexing capability. The resolution of incremental SigmaDeltamodulators can be improved significantly by means of a technique similar to extended counting. In this scheme, the A/D conversion is accomplished in a two-step process resulting in enhanced resolution and an improved integral nonlinearity (INL) at lower oversampling ratios than would otherwise be possible. Calibration-free operation is an advantage of the proposed architecture.
An experimental implementation of the proposed modulator has been integrated in a 0.18mum CMOS technology. Operating form a 1.8V supply, it achieves a dynamic range of 90.1 dB and a peak SNDR of 86.3dB at a conversion rate of 1MSample/s with 38mW power consumption. It occupies an active area of 3.5mm 2.
附註
Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6166.
Adviser: James D. Plummer.
Thesis (Ph.D.)--Stanford University, 2007.
數位化論文典藏聯盟
合著者
ISBN/ISSN
9780549242604