Design, simulation, fabrication and testing of an implantable micropump for use in medical drug delivery systems [electronic resource] / Li Cao

Cao, Li
Bib ID
vtls000568621
稽核項
180 p.
電子版
附註項
數位化論文典藏聯盟
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$a Design, simulation, fabrication and testing of an implantable micropump for use in medical drug delivery systems $h [electronic resource] / $c Li Cao
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$a Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 3243.
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$a An implantable micropump for use in medical drug delivery systems was designed, simulated, fabricated and tested. The overall size of the micropump is 70mm x 35mm x 1.5mm. The micropump was designed to deliver up to 10μL/min of liquid. The design of the micropump is a sandwich structure (glass-silicon-glass), including three pump chambers (&phis;12mm x 40μm), inlet, outlet and flow channels connecting the pump chambers. To prohibit flow when no power is applied, the micropump was designed to be normally closed. The pump features an integral valve/membrane design such that the membranes not only pump the liquid, but also function as the inlet and outlet valves. Three pump chambers were actuated individually by three microactuators. Commercially available bulk PZT (lead zirconate titanate) disks (&phis;12mm x 200μm) were used as actuators. The three pump chambers were actuated at 100 volts and 0.56 Hz in a peristaltic motion. Analysis and simulation (Finite Element Analysis) of electromechanical coupled field of the micropump chamber were conducted to evaluate the pumping stroke and to ensure that fluid flows freely within the pump. A micropump made of silicon materials and Pyrex glass was fabricated using integrated circuit fabrication technology. Analysis and experimental data indicated that the stroke was approximately 2μm for a 12mm diameter and 40μm thick membrane. Although this stroke is sufficient to open the pump valve, it is insufficient to move fluid through the pump. Several alternate approaches for increasing membrane stroke were proposed.
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$a 數位化論文典藏聯盟 $b PQDT $c 中山大學(2001~2002)
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摘要
An implantable micropump for use in medical drug delivery systems was designed, simulated, fabricated and tested. The overall size of the micropump is 70mm x 35mm x 1.5mm. The micropump was designed to deliver up to 10μL/min of liquid. The design of the micropump is a sandwich structure (glass-silicon-glass), including three pump chambers (&phis;12mm x 40μm), inlet, outlet and flow channels connecting the pump chambers. To prohibit flow when no power is applied, the micropump was designed to be normally closed. The pump features an integral valve/membrane design such that the membranes not only pump the liquid, but also function as the inlet and outlet valves. Three pump chambers were actuated individually by three microactuators. Commercially available bulk PZT (lead zirconate titanate) disks (&phis;12mm x 200μm) were used as actuators. The three pump chambers were actuated at 100 volts and 0.56 Hz in a peristaltic motion. Analysis and simulation (Finite Element Analysis) of electromechanical coupled field of the micropump chamber were conducted to evaluate the pumping stroke and to ensure that fluid flows freely within the pump. A micropump made of silicon materials and Pyrex glass was fabricated using integrated circuit fabrication technology. Analysis and experimental data indicated that the stroke was approximately 2μm for a 12mm diameter and 40μm thick membrane. Although this stroke is sufficient to open the pump valve, it is insufficient to move fluid through the pump. Several alternate approaches for increasing membrane stroke were proposed.
附註
Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 3243.
Adviser: Susan C. Mantell.
Thesis (Ph.D.)--University of Minnesota, 2000.
數位化論文典藏聯盟
合著者
ISBN/ISSN
0599814217